SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively.
SEL-201 displays acceptable kinome selectivity in the broad KINOMEscan (450 distinct kinases).
SEL-201 potently suppresses MNK1/2 activity in a panel of KIT-mutant melanoma cell lines.
SEL-201 reduces clonogenicity, migration, and lung metastasis of KIT-mutant melanoma cells both in vitro and in vivo.
