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Chemical Structure : SEL-201
CAS No.: 2095704-43-9
Catalog No.: PC-62742Not For Human Use, Lab Use Only.
SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $268 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote |
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SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively.
SEL-201 displays acceptable kinome selectivity in the broad KINOMEscan (450 distinct kinases).
SEL-201 potently suppresses MNK1/2 activity in a panel of KIT-mutant melanoma cell lines.
SEL-201 reduces clonogenicity, migration, and lung metastasis of KIT-mutant melanoma cells both in vitro and in vivo.
| M.Wt | 350.806 | |
| Formula | C19H15ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one |
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1. Zhan Y, et al. J Clin Invest. 2017 Nov 1;127(11):4179-4192.
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