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SEMBL

Chemical Structure : SEMBL

CAS No.: 1443448-82-5

SEMBL (NF-κB inhibitor)

Catalog No.: PC-62804Not For Human Use, Lab Use Only.

SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.

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Biological Activity

SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
SEMBL inhibits LPS-induced NF-κB activation, iNOS expression, and inflammatory cytokine secretions.
SEMBL also inhibits NF-κB and cellular invasion in ovarian carcinoma ES-2 cells.
SEMBL enhances stability in aqueous solution compared with (-)-DHMEQ.

Physicochemical Properties

M.Wt 233.223
Formula C12H11NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-hydroxy-N-(4-methylene-5-oxotetrahydrofuran-3-yl)benzamide

References

1. Sidthipong K, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):562-566.

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