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Chemical Structure : SEN461
Catalog No.: PC-49508Not For Human Use, Lab Use Only.
SEN461 (SEN 461) is a potent small molecule inhibitor of canonical WNT signaling, inhibits WNT reporter activity in the DBTRG cell line with IC50 of 1.3 uM, acts through AXIN stabilization.
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SEN461 (SEN 461) is a potent small molecule inhibitor of canonical WNT signaling, inhibits WNT reporter activity in the DBTRG cell line with IC50 of 1.3 uM, acts through AXIN stabilization.
SEN461 inhibits WNT-induced transcriptional activity and suppresses anchorage independent growth of DBTRG cells.
SEN461 increases AXIN and decreases β-CATENIN levels in DBTRG cells
SEN461 affects canonical WNT ligands mediated transcription and modulates molecular markers of the pathway.
SEN461 inhibits XWnt8-induced axis duplication in Xenopus embryos.
SEN461 shows significant in vitro activity across the panel of GBM cells with IC50 from 0.5 to 3.5 μM.
SEN461 at 30 mg/kg BID shows tumor growth inhibition of DBTRG xenograft model.
| M.Wt | 486.57 | |
| Formula | C25H34N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. De Robertis A, et al. Mol Cancer Ther. 2013 Jul;12(7):1180-9.
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