Chemical Structure : SEW2871
CAS No.:
256414-75-2
SEW2871
(SEW-2871;SEW 2871)
Catalog No. : PC-60766Not For Human Use, Lab Use Only.
SEW2871 is a potent, selective S1P1 receptor full agonist with EC50 of 13.8 nM, with no activites at the S1P2-5 receptors.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6076601
Biological Activity
SEW2871 is a potent, selective S1P1 receptor full agonist with EC50 of 13.8 nM, with no activites at the S1P2-5 receptors.
Physicochemical Properties
M.Wt
440.4
Formula
C20H10F6N2OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
References
1. Jo E, et al. Chem Biol. 2005 Jun;12(6):703-15.
2. Wei SH, et al. Nat Immunol. 2005 Dec;6(12):1228-35.
3. Lien YH, et al. Kidney Int. 2006 May;69(9):1601-8.
4. Whetzel AM, et al. Circ Res. 2006 Sep 29;99(7):731-9.
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