Chemical Structure : SF-9-2
CAS No.:
3053768-78-5
SF-9-2
Catalog No.: PC-25370Not For Human Use, Lab Use Only.
SF-9-2 is a potent, small molecule inhibitor of PD-1/PD-L1 binding with IC50 of 24.9 nM in HTRF assays, effectively suppresses the viability of NB cell line SK-N-SH with high PD-L1 expression with IC50 of 5.9 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SF-9-2 is a potent, small molecule inhibitor of PD-1/PD-L1 binding with IC50 of 24.9 nM in HTRF assays, effectively suppresses the viability of NB cell line SK-N-SH with high PD-L1 expression with IC50 of 5.9 uM.
SF-9-2 inhibits the proliferation, migration, invasion, and EMT of SK-N-SH cells.
SF-9-2 (3 uM) induces mitochondrial-dependent apoptosis in SK-N-SH cells.
SF-9-2 exerts its antitumor effects by modulating MAPK pathway activity in SK-N-SH cells, SF-9-2 (5 uM) significantly reduced PD-L1 levels in SK-N-SH cells.
SF-9-2-mediated regulation of ERK phosphorylation is linked to PD-L1 inhibition.
SF-9-2 induces PD-L1 internalization and ubiquitin-proteasome pathway degradation mediated by GSK-3β.
SF-9-2 (40 mg/kg, i.p.) suppresses SK-N-SH tumor growth in SK-N-SH NOG mouse model.
SF-9-2 also acted as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function.
Physicochemical Properties
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M.Wt
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515.56
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Formula
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C30H27F2N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-((5-((2'-fluoro-2-(fluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)-2-(((2-hydroxyethyl)amino)methyl)phenoxy)methyl)nicotinonitrile
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References
1. Wang J, et al. ACS Pharmacol Transl Sci. 2025 Jul 7;8(8):2612-2629.
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