SF0034 | Kv7.2/7.3 activator | Probechem Biochemicals

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Chemical Structure : SF0034

SF0034 (SF-0034)

Catalog No.: PC-27791Not For Human Use, Lab Use Only.

SF0034 is a potent, sepcific KCNQ2/3 (Kv7.2/7.3) channel activator, shiftes the V1/2 of KCNQ2/3 currents with EC50 of 1.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SF0034 is a potent, sepcific KCNQ2/3 (Kv7.2/7.3) channel activator, shiftes the V1/2 of KCNQ2/3 currents with EC50 of 1.3 uM.
SF0034 is five times more potent than retigabine at shifting the voltage dependence of KCNQ2/3 channels to more negative voltages.
SF0034 does not shift the voltage dependence of either KCNQ4 or KCNQ5 homomeric channels.
SF0034 activates neuronal KCNQ2/3 channels and controls neuronal excitability.
SF0034 exhibits stronger anticonvulsant activity and is less toxic than retigabine.
SF0034 prevents the development of tinnitus.

Physicochemical Properties

M.Wt	321.33
Formula	C16H17F2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (2-amino-3-fluoro-4-((4-fluorobenzyl)amino)phenyl)carbamate

References

1. Kalappa BI, et al. J Neurosci. 2015 Jun 10;35(23):8829-42.

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SF0034 (SF-0034)

Biological Activity

Physicochemical Properties

References

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