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SF0166

Chemical Structure : SF0166

CAS No.: 1621332-91-9

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SF0166 (Nesvategrast, SF 0166, SF-0166)

Catalog No.: PC-35164Not For Human Use, Lab Use Only.

SF0166 (Nesvategrast, SF-0166) is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SF0166 (Nesvategrast, SF-0166) is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.
    SF0166 inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 of 7.6 pM-76 nM。
    SF0166 significantly decreases neovascularization in the oxygen-induced retinopathy mouse models.

    Physicochemical Properties

    M.Wt 475.497
    Formula C23H27F2N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(6-(difluoromethoxy)pyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid

    References

    1. Askew BC, et al. J Pharmacol Exp Ther. 2018 May 31. pii: jpet.118.248427.

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