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SG3-014

Chemical Structure : SG3-014

CAS No.: 1877286-49-1

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SG3-014 (SG3014, SG3)

Catalog No.: PC-28345Not For Human Use, Lab Use Only.

SG3-014 (SG3) is a small-molecule multi-kinases inhibitor targeting ULK3, inhibits BRD4, JAK2 and ULK3 with IC50 of 9.3, 4.6 and 204 nM respectively, shows considerably weaker activity against ULK1 (IC50=539 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SG3-014 (SG3) is a small-molecule multi-kinases inhibitor targeting ULK3, inhibits BRD4, JAK2 and ULK3 with IC50 of 9.3, 4.6 and 204 nM respectively, shows considerably weaker activity against ULK1 (IC50=539 nM).
SG3-014 (SG3) rapidlyreduced ULK3/ULK1levels (6h), altered early autophagy proteins (e.g., Beclin-1), and suppresses
autophagic flux and cell survival effects.
SG3-014 (SG3) inhibits osteoclastogenesis without affecting MSCsor osteoblasts.

Physicochemical Properties

M.Wt 544.12
Formula C26H34ClN7O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-chloro-5-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2-methylpropane-2-sulfonamide

References

1. Tauro M, et al. Nat Commun. 2026 Aug 25;17(1):10142.

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