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Chemical Structure : SGA360
CAS No.: 680611-86-3
Catalog No.: PC-38513Not For Human Use, Lab Use Only.
SGA360 is a high-affinity, selective modulator of aryl hydrocarbon receptor (AhR), competitively binds to AhR (IC50 =3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells.
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|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
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| 100 mg | Get quote |
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SGA360 is a high-affinity, selective modulator of aryl hydrocarbon receptor (AhR), competitively binds to AhR (IC50 =3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells.
SGA360 reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema.
SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis.
| M.Wt | 362.352 | |
| Formula | C19H17F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-allyl-3-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole |
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1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27.
2. van den Bogaard EH, et al. J Invest Dermatol. 2015 May;135(5):1320-1328.
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