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SGA360

Chemical Structure : SGA360

CAS No.: 680611-86-3

SGA360 (SGA 360)

Catalog No.: PC-38513Not For Human Use, Lab Use Only.

SGA360 is a high-affinity, selective modulator of aryl hydrocarbon receptor (AhR), competitively binds to AhR (IC50 =3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells.

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Biological Activity

SGA360 is a high-affinity, selective modulator of aryl hydrocarbon receptor (AhR), competitively binds to AhR (IC50 =3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells.
SGA360 reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema.
SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis.

Physicochemical Properties

M.Wt 362.352
Formula C19H17F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-allyl-3-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole

References

1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27.

2. van den Bogaard EH, et al. J Invest Dermatol. 2015 May;135(5):1320-1328.

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