SGC-CK2-1 analog 2h

Chemical Structure : SGC-CK2-1 analog 2h

Catalog No.: PC-20908Not For Human Use, Lab Use Only.

SGC-CK2-1 analog 2h is potent, selective and in vivo active inhibitor of casein kinase 2α (CSNK2A, CK2α) with pIC50 of 7.5 and 7.7 against CSNK2A1 and CSNK2A2, respectively.

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Biological Activity

SGC-CK2-1 analog 2h is potent, selective and in vivo active inhibitor of casein kinase 2α (CSNK2A, CK2α) with pIC50 of 7.5 and 7.7 against CSNK2A1 and CSNK2A2, respectively.
SGC-CK2-1 analog 2h inhibits mouse β-CoV replication using an MHV-nLuc assay in DBT cells with pIC50 of 7.1.

Physicochemical Properties

M.Wt	432.49
Formula	C22H24N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CC(NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N5CCOCC5)=O

References

1. Yang X, et al. bioRxiv. 2023 May 18:2023.05.15.540828.

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