SGC-CK2-2 | CK2 inhibitor | Probechem Biochemicals

Chemical Structure : SGC-CK2-2

SGC-CK2-2 (CK2 inhibitor, Casein kinase 2 inhibitor)

Catalog No.: PC-22407Not For Human Use, Lab Use Only.

SGC-CK2-2 is a potent, selective casein kinase 2 (CSNK2, CK2) chemical probe inhibitor with IC50 of 0.2 uM, shows much improved kinase selectivity compared with silmitasertib (CX-4945).

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Biological Activity

SGC-CK2-2 is a potent, selective casein kinase 2 (CSNK2, CK2) chemical probe inhibitor with IC50 of 0.2 uM, shows much improved kinase selectivity compared with silmitasertib (CX-4945).
SGC-CK2-2 shows high selectivity (3/403 kinases) in DiscoverX KINOMEscan showing 90% inhibition at 1 µM.
SGC-CK2-2 demonstrated inhibition of viral replication with IC50 of 10-20 uM in MHV-NLuc in DBT cells.

Physicochemical Properties

M.Wt	330.35
Formula	C19H14N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(benzylamino)pyrimido[4,5-c]quinoline-8-carboxylic acid

References

1. Asressu KH, et al. Pharmaceuticals (Basel). 2024 Feb 27;17(3):306.

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SGC-CK2-2 (CK2 inhibitor, Casein kinase 2 inhibitor)

Biological Activity

Physicochemical Properties

References

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