Chemical Structure : SGC-NSP2PRO-1
CAS No.:
SGC-NSP2PRO-1
Catalog No.: PC-24207Not For Human Use, Lab Use Only.
SGC-NSP2PRO-1 is a potent, covalent inhibitor of Chikungunya virus (CHIKV) nsP2 cysteine protease (nsP2pro) with IC50 of 40 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SGC-NSP2PRO-1 is a potent, covalent inhibitor of Chikungunya virus (CHIKV) nsP2 cysteine protease (nsP2pro) with IC50 of 40 nM.
SGC-NSP2PRO-1 inhibits CHIKV nsP2 protease activity in a time-dependent manner.
SGC-NSP2PRO-1 is > 30-fold selective for CHIKV nsP2pro over the other cysteine proteases.
SGC-NSP2PRO-1 demonstrated potent inhibition of alphaviral replication using the CHIKV-nLuc and VEEV-nLuc reporter viruses with EC50= 0.05 and 0.5 µM, respectively.
SGC-NSP2PRO-1 also shows potential pan-alphaviral activity for the reduction viral titer against infectious isolates of CHIKV, MAYV, and VEEV.
Physicochemical Properties
|
M.Wt
|
350.39
|
|
Formula
|
C16H18N2O5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(E)-3-(2-ethoxyphenyl)-N-(3-(methylsulfonyl)allyl)isoxazole-5-carboxamide
|
References
1. Ghoshal, A. et al. J. Med. Chem. 67, 16505–16532.
2. Anirban Ghoshal, et al. Res Sq. [Preprint]. 2024 Nov 12:rs.3.rs-5363451.
3. Ghoshal A, et al. Sci Rep. 2025 Mar 1;15(1):7264.
Contact Us
sales@probechem.com
