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Chemical Structure : SGC-STK17B-1
Catalog No.: PC-38222Not For Human Use, Lab Use Only.
SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A.
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SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A.
SGC-STK17B-1 is also >100-fold selective over all of the other kinases tested, with only STK17A, CAMKK1, and AURKB (IC50s=5-9 uM) in panel of 403 wild type human kinase assays.
SGC-STK17B-1 demonstrated the highest cell potency in the NanoBRET target engagement assay (IC50=190 nM).
SGC-STK17B-1 is the first truly potent and selective chemical probe of STK17B.
| M.Wt | 358.448 | |
| Formula | C16H10N2O2S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alfredo Picado, et al. J Med Chem. 2020 Dec 10;63(23):14626-14646.
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