Chemical Structure : SH-273
CAS No.:
3084159-97-4
SH-273
(SH273)
Catalog No.: PC-26653Not For Human Use, Lab Use Only.
SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM).
SH-273 abolished the STING-induced IRF3 phosphorylation in B cells from splenocytes of KPC PDAC mice.
SH-273 eliminated STING-induced expansion of IL35+ and IL10+ Breg cells in the splenocytes from KPC mice.
Albumin nanoformulation of SH-273 (Nano-273) decreases Breg cells and remodels microenvironment in tumors and lymph nodes, extended median survival to 200 days in transgenic KPC PDAC mice (KrasG12D-P53R172H-Cre) when combined with anti-PD-1.
Physicochemical Properties
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M.Wt
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852.88
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Formula
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C43H36N10O8S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-(4-(3-(1-(2-aminopyrazolo[1,5-a]pyrimidine-3-carboxamido)ethyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-8-yl)-1H-1,2,3-triazol-1-yl)ethyl 3-(6,7-dimethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[4,5]thieno[2,3-c]pyrrol-2-yl)propanoate
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References
1. Li C, et al. Dual targeting of PI3Kγ and STING overcomes regulatory B cell- and myeloid cell-driven immune suppression in pancreatic cancer. Nat Cancer. 2026 Apr 28. doi: 10.1038/s43018-026-01158-7.
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