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Chemical Structure : SHA68
CAS No.: 847553-89-3
Catalog No.: PC-38622Not For Human Use, Lab Use Only.
SHA68 is a selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively, Ke value of 13.7 nM (Ile107 variant).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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SHA68 is a selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively, Ke value of 13.7 nM (Ile107 variant).
SHA68 induced antidepressant-like effects in bed nucleus of the stria terminalis (BNST) of learned helplessness (LH) rats (an animal model of depression).
| M.Wt | 445.494 | |
| Formula | C26H24FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide |
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1. Medina G, et al. Mol Pain. 2014 May 29;10:32.
2. Hassler C, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):731-44.
3. Shirayama Y, et al. Behav Brain Res. 2015 Sep 15;291:67-71.
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