SHR3824 | SGLT2 inhibitor | Probechem Biochemicals

Chemical Structure : SHR3824

SHR3824 (Henagliflozin, SHR-3824)

Catalog No.: PC-63374Not For Human Use, Lab Use Only.

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.

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Biological Activity

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.
SHR3824 exhibits antidiabetic efficacy in several rodent models.

Physicochemical Properties

M.Wt	454.875
Formula	C22H24ClFO7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

References

1. Yan PK, et al. Acta Pharmacol Sin. 2014 May;35(5):613-24. doi: 10.1038/aps.2013.196.

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SHR3824 (Henagliflozin, SHR-3824)

Biological Activity

Physicochemical Properties

References

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