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SHR3824

Chemical Structure : SHR3824

CAS No.: 1358579-22-2

SHR3824 (Henagliflozin, SHR-3824)

Catalog No.: PC-63374Not For Human Use, Lab Use Only.

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.
    SHR3824 exhibits antidiabetic efficacy in several rodent models.

    Physicochemical Properties

    M.Wt 454.875
    Formula C22H24ClFO7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

    References

    1. Yan PK, et al. Acta Pharmacol Sin. 2014 May;35(5):613-24. doi: 10.1038/aps.2013.196.

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