SIAIS630121 | NAMPT PROTAC | Probechem Biochemicals

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Chemical Structure : SIAIS630121

SIAIS630121 (NAMPT PROTAC)

Catalog No.: PC-22771Not For Human Use, Lab Use Only.

SIAIS630121 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIAIS630121 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner.

Physicochemical Properties

M.Wt	826.06
Formula	C49H59N7O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-(1-(4-(4-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)benzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide

References

1. Xiaotong Zhu, et al. Cell Chem Biol. 2022 Nov 17;29(11):1616-1629.e12.

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