SIK1 inhibitor 27

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Chemical Structure : SIK1 inhibitor 27

Catalog No.: PC-25523Not For Human Use, Lab Use Only.

SIK1 inhibitor 27 is a potent, isoform-selective SIK1 inhibitor with IC50 of 0.7 nM, >100-fold selectivity against SIK2 and SIK3.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIK1 inhibitor 27 is a potent, isoform-selective SIK1 inhibitor with IC50 of 0.7 nM, >100-fold selectivity against SIK2 and SIK3.
SIK1 inhibitor 27 exhibits more than 400-fold selectivity against SIK2 and SIK3 in the NanoBRET binding assay.
SIK1 inhibitor 27 exhibits IC50 values below 100 nM for SIK1 in a cellular context.
SIK1 inhibitor 27 represents a valuable tool compound to dissect the role of SIK1 versus other SIK isoforms in physiological processes.

Physicochemical Properties

M.Wt	409.87
Formula	C21H20ClN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chloro-2,6-dimethylphenyl)-6-methoxy-7-(1-methyl-1H-pyrazol-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

References

1. Peixoto C, et al. Bioorg Med Chem Lett. 2025 Sep 8:130397.

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