SIK inhibitor M22

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Chemical Structure : SIK inhibitor M22

Catalog No.: PC-20809Not For Human Use, Lab Use Only.

SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.
SIK inhibitor M22 displays excellent selectivity in a representative kinase panel, including STE group kinases.
SIK inhibitor M22 treatment caused centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells, as observed with MRIA9 (Cat. PC-72723), conclusively linking these phenotypic effects to SIK inhibition.
MR22 is a valuable tool compound for studying SIK kinase function in cells.

Physicochemical Properties

M.Wt	359.38
Formula	C18H19F2N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1C(C2=CC(F)=CC=C2F)=CC3=CN=C(NC)N=C3N1CCCCN

References

1. Rak M, et al. Eur J Med Chem. 2023 Jun 5;254:115347.

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