Catalog No.: PC-43323Not For Human Use, Lab Use Only.
SIS3 (Specific Inhibitor of Smad3) is a potent, selective inhibitor of Smad3 function and TGF-β signaling, attenuates the TGF-β1-induced phosphorylation of Smad3 (IC50=3 uM) and interaction of Smad3 with Smad4.
SIS3 (Specific Inhibitor of Smad3) is a potent, selective inhibitor of Smad3 function and TGF-β signaling, attenuates the TGF-β1-induced phosphorylation of Smad3 (IC50=3 uM) and interaction of Smad3 with Smad4.
SIS3 decreases the levels of the DNA-Smad3 binding by approximately 50% at 3 uM; shows no effect on phosphorylated levels of Smad2, Smad4 and Smad7, as well as the phosphorylation of other signaling pathways, such as MAPK/p38.
SIS3 attenuates the effects of TGF-beta1 by reducing the transcriptional activity, also inhibits the myofibroblast differentiation of fibroblasts by TGF-beta1, completely diminishes the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts.
