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SJF-8240

Chemical Structure : SJF-8240

CAS No.: 2230821-68-6

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SJF-8240 (SJF8240, Foretinib-Based PROTAC 7)

Catalog No.: PC-35356Not For Human Use, Lab Use Only.

SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.

Physicochemical Properties

M.Wt 1106.253
Formula C58H65F2N7O11S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic

References

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.

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