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Chemical Structure : SJF-8240
CAS No.: 2230821-68-6
Catalog No.: PC-35356Not For Human Use, Lab Use Only.
SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
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SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
| M.Wt | 1106.253 | |
| Formula | C58H65F2N7O11S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic |
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1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.
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