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Chemical Structure : SJF620
CAS No.: 2376187-16-3
Catalog No.: PC-22653Not For Human Use, Lab Use Only.
SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).
SJF620 displays superior pharmacokinetic profiles relative to MT-802, with exhibiting a more robust clearance and exposure profile.
| M.Wt | 760.85 | |
| Formula | C41H44N8O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(5-(2-(2-(2-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
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1. Jaime-Figueroa S, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877.
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