SJF620 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : SJF620

CAS No.: 2376187-16-3

SJF620 (SJF 620, SJF-620)

Catalog No.: PC-22653Not For Human Use, Lab Use Only.

SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).

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5 mg	$488	In stock
10 mg	$788	In stock
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Biological Activity

SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).
SJF620 displays superior pharmacokinetic profiles relative to MT-802, with exhibiting a more robust clearance and exposure profile.

Physicochemical Properties

M.Wt	760.85
Formula	C41H44N8O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(2-(2-(2-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Jaime-Figueroa S, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877.

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SJF620 (SJF 620, SJF-620)

Biological Activity

Physicochemical Properties

References

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