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Chemical Structure : SJPYT-310
Catalog No.: PC-22399Not For Human Use, Lab Use Only.
SJPYT-310 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 4 nM, antagonistic IC50 of 9 nM.
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SJPYT-310 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 4 nM, antagonistic IC50 of 9 nM.
SJPYT-310 is selective for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR.
SJPYT-310 shows only marginal cytotoxicity in the cell models used (HepG2 and HEK293), and in hepatoma cells Hepa 1–6 and HepaRG.
| M.Wt | 464.61 | |
| Formula | C27H36N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Garcia-Maldonado E, et al. Nat Commun. 2024 May 14;15(1):4054.
2. Yongtao Li, et al. J Med Chem. 2022 Dec 22;65(24):16829-16859.
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