SJPYT-318 | PXR agonist | Probechem Biochemicals

Chemical Structure : SJPYT-318

SJPYT-318 (SJPYT318)

Catalog No.: PC-21198Not For Human Use, Lab Use Only.

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.

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Biological Activity

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.
SJPYT-318 is strongly selective for PXR in cellular reporter activation, showing only marginal activation of both LXRα and LXRβ.

Physicochemical Properties

M.Wt	581.53
Formula	C28H21F6NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(4-phenoxybenzyl)benzenesulfonamide

References

1. Huber AD, et al. Structure. 2023 Sep 5:S0969-2126(23)00297-6.

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SJPYT-318 (SJPYT318)

Biological Activity

Physicochemical Properties

References

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