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SJW-2C-227

Chemical Structure : SJW-2C-227

CAS No.: 693821-95-3

SJW-2C-227

Catalog No.: PC-20019Not For Human Use, Lab Use Only.

SJW-2C-227 is a broad-spectrum anti-viral compound that target enterovirus 2C potein, inhibits 2C ATPase activity, exhibits anti-viral activity of SJW-2C-227 with an EC50 of 1.7 µM against EVA71 and 0.52 µM against EV-D68.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJW-2C-227 is a broad-spectrum anti-viral compound that target enterovirus 2C potein, inhibits 2C ATPase activity, exhibits anti-viral activity of SJW-2C-227 with an EC50 of 1.7 µM against EVA71 and 0.52 µM against EV-D68.
SJW-2C-227 inhibited the virus-induced CPE with an IC50 of 2.66 µM, inhibited the ATPase function of Δ2C116-329 with a clear dose-dependent response.
SJW-2C-227 binds to recombinant EV-A71 2C protein in vitro, does not inhibit the EV-A71 replicon system.
SJW-2C-227 is highly potent against EV-D68 with an IC50 value of 0.85 µM and PV-1 strain with an IC50 of 1.7 µM.

Physicochemical Properties

M.Wt 333.41
Formula C19H15N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl)thiophene-2-carboxamide

References

1. Kejriwal R, et al. ChemMedChem. 2023 Feb 15:e202200541.

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