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SK-017154-O

Chemical Structure : SK-017154-O

CAS No.: 133978-91-3

SK-017154-O

Catalog No.: PC-20696Not For Human Use, Lab Use Only.

SK-017154-O is a specific and noncompetitive inhibitor of PelA, specifically inhibits PelA esterase activity with IC50 of 11 uM, inhibits Pel-dependent PA14 biofilms with IC50 of 1.8 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SK-017154-O is a specific and noncompetitive inhibitor of PelA, specifically inhibits PelA esterase activity with IC50 of 11 uM, inhibits Pel-dependent PA14 biofilms with IC50 of 1.8 uM.
SK-017154-O does not inhibit PA14 growth at concentrations that inhibit biofilm production.
SK-017154-O inhibits both P. aeruginosa and B. cereus ATCC 10987 Pel-dependent biofilm formation.

Physicochemical Properties

M.Wt 211.30
Formula C8H9N3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 2-(2-pyridinylmethylene) hydrazinecarbodithioate

References

1. Razvi E, et al. Microbiol Spectr. 2023 Apr 26:e0029623.

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