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Chemical Structure : SK-216
Catalog No.: PC-61650Not For Human Use, Lab Use Only.
SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.
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SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.
SK-216 reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model.
SK-216 also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.
| M.Wt | 533.52 | |
| Formula | C29H29NO6Na2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88.
2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9.
3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94.
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