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SK-575

Chemical Structure : SK-575

CAS No.: 2523016-96-6

SK-575 (SK575)

Catalog No.: PC-27298Not For Human Use, Lab Use Only.

SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations.

Physicochemical Properties

M.Wt 876.99
Formula C47H53FN8O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide

References

1. Chaoguo Cao, et al. J Med Chem. 2020 Oct 8;63(19):11012-11033.

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