Chemical Structure : SK2188
CAS No.:
3038446-94-2
SK2188
(SK-2188)
Catalog No.: PC-24083Not For Human Use, Lab Use Only.
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN.
SK2188 displays excellent AURKA binding and degradation selectivity.
SK2188 potently inhibits cell growth with IC50 of 31.9 nM in NGP cells, triggers apoptosis and results in elevated DNA damage and replicative stress markers.
SK2188 anti-proliferative activity varies across NB cell lines and patient-derived organoids.
Physicochemical Properties
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M.Wt
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893.38
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Formula
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C43H46ClFN6O10S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1r,4r)-4-(3-chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
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References
1. Rishfi M, et al. Eur J Med Chem. 2023 Feb 5;247:115033.
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