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Chemical Structure : SKA-111
CAS No.: 1369170-24-0
Catalog No.: PC-60781Not For Human Use, Lab Use Only.
SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM.
SKA-111 displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels.
SKA-111 not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice.
| M.Wt | 214.286 | |
| Formula | C12H10N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-methylnaphtho[1,2-d]thiazol-2-amine |
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1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.
2. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.
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