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Chemical Structure : SKA-121
CAS No.: 1820708-73-3
Catalog No.: PC-60780Not For Human Use, Lab Use Only.
SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM.
SKA-121 displays 41-fold selectivity over KCa2.3 (EC50=4.4 uM), and 200- to 400-fold selectivity over representative KV, NaV, as well as CaV1.2 channels.
SKA-121 significantly lowers mean arterial blood pressure in normotensive and hypertensive mice.
| M.Wt | 198.225 | |
| Formula | C12H10N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-methylnaphtho[2,1-d]oxazol-2-amine |
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1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.
2. Christophersen P, et al. Channels (Austin). 2015;9(6):336-43.
3. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.
4. Brown BM, et al. Mol Pharmacol. 2017 Oct;92(4):469-480.
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