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Chemical Structure : SKA-31
CAS No.: 40172-65-4
Catalog No.: PC-47099Not For Human Use, Lab Use Only.
SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.
SKA-31 activated native KCa2.3 and KCa3.1 channels in murine endothelial cells, and potentiated endothelium-derived hyperpolarizing factor-mediated dilations of carotid arteries from KCa3.1(+/+) mice but not from KCa3.1(-/-) mice.
Administration of 10 and 30 mg/kg SKA-31 lowered mean arterial blood pressure by 4 and 6 mm Hg in normotensive mice and by 12 mm Hg in angiotensin-II-induced hypertension.
| M.Wt | 200.259 | |
| Formula | C11H8N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
naphtho[1,2-d]thiazol-2-ylamine |
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1. Sankaranarayanan A, et al. Mol Pharmacol. 2009 Feb;75(2):281-95.
2. Parajuli SP, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):114-23.
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