SKA-346 | KCa3.1 activator | Probechem Biochemicals

Chemical Structure : SKA-346

SKA-346 (SKA346)

Catalog No.: PC-23603Not For Human Use, Lab Use Only.

SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM.

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Biological Activity

SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM.
SKA-346 (30 mg kg−1), tolerated by mice after intra-peritoneal administration, exhibited a peak plasma concentration of 6.29 μg mL−1 (29.2 μM) at 15 min and a circulating half-life (t1/2) of 2.8 h.

Physicochemical Properties

M.Wt	215.27
Formula	C11H9N3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-[1,3]thiazolo[4,5-f]quinolin-2-amine

References

1. Wong BHS, et al. RSC Adv. 2024 Dec 4;14(52):38364-38377.

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SKA-346 (SKA346)

Biological Activity

Physicochemical Properties

References

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