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SKF-89976A hydrochloride

Chemical Structure : SKF-89976A hydrochloride

CAS No.: 85375-15-1

SKF-89976A hydrochloride (SKF89976A hydrochloride)

Catalog No.: PC-42093Not For Human Use, Lab Use Only.

SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.
SKF-89976A shows little to no activity for rGAT-2, hGAT-3 and hBGT-1 (IC50>500 uM).
SKF-89976A blocks GABA uptake and uncoupled transmitter-gated current with Ki of 7 uM and 0.03 uM, respectively.

Physicochemical Properties

M.Wt 371.9003
Formula C22H26ClNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1)

References

1. Ali FE, et al. J Med Chem. 1985 May;28(5):653-60.

2. Stringer JL, et al. Epilepsy Res. 2002 Dec;52(2):129-37.

3. Krause S, et al. Mol Pharmacol. 2005 Dec;68(6):1728-35.

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