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Chemical Structure : SKF-89976A hydrochloride
CAS No.: 85375-15-1
Catalog No.: PC-42093Not For Human Use, Lab Use Only.
SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.
SKF-89976A shows little to no activity for rGAT-2, hGAT-3 and hBGT-1 (IC50>500 uM).
SKF-89976A blocks GABA uptake and uncoupled transmitter-gated current with Ki of 7 uM and 0.03 uM, respectively.
| M.Wt | 371.9003 | |
| Formula | C22H26ClNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1) |
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1. Ali FE, et al. J Med Chem. 1985 May;28(5):653-60.
2. Stringer JL, et al. Epilepsy Res. 2002 Dec;52(2):129-37.
3. Krause S, et al. Mol Pharmacol. 2005 Dec;68(6):1728-35.
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