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SKF83959

Chemical Structure : SKF83959

CAS No.: 80751-85-5

SKF83959 (SKF 83959)

Catalog No.: PC-25926Not For Human Use, Lab Use Only.

SKF83959 is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKF83959 is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities.

Physicochemical Properties

M.Wt 317.81
Formula C18H20ClNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-chloro-3-methyl-1-(m-tolyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol

References

1. Panchalingam S, et al. Neuropharmacology. 2001 May;40(6):826-37.

2. Jin LQ, et al. J Neurochem. 2003 Apr;85(2):378-86.

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