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SKI-178

Chemical Structure : SKI-178

CAS No.: 1259484-97-3

SKI-178 (SKI178)

Catalog No.: PC-61768Not For Human Use, Lab Use Only.

SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
SKI-178 induces apoptosis in human AML cell lines in a CDK1-dependent manner and is not a substrate for MDR1.
SKI-178 shows effectivity in mouse models of AML.

Physicochemical Properties

M.Wt 394.42
Formula C21H22N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

References

1. Hengst JA, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7498-502.

2. Dick TE, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):494-508.

3. Hengst JA, et al. Cancer Transl Med. 2017 Jul-Aug;3(4):109-121.

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