Chemical Structure : SKI-178
CAS No.:
1259484-97-3
SKI-178
(SKI178)
Catalog No. : PC-61768Not For Human Use, Lab Use Only.
SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
Packing Price Stock Quantity 5 mg $78 In stock 0 1 2 3 4 5 10 mg $118 In stock 0 1 2 3 4 5 25 mg $198 In stock 0 1 2 3 4 5 50 mg $348 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6176801
Biological Activity
SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
Physicochemical Properties
M.Wt
394.42
Formula
C21H22N4O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
References
1. Hengst JA, et al. Bioorg Med Chem Lett.
2. Dick TE, et al. J Pharmacol Exp Ther.
3. Hengst JA, et al. Cancer Transl Med.
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