Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SKI-178
CAS No.: 1259484-97-3
Catalog No.: PC-61768Not For Human Use, Lab Use Only.
SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
SKI-178 induces apoptosis in human AML cell lines in a CDK1-dependent manner and is not a substrate for MDR1.
SKI-178 shows effectivity in mouse models of AML.
| M.Wt | 394.42 | |
| Formula | C21H22N4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide |
|
1. Hengst JA, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7498-502.
2. Dick TE, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):494-508.
3. Hengst JA, et al. Cancer Transl Med. 2017 Jul-Aug;3(4):109-121.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
