Catalog No.: PC-61137Not For Human Use, Lab Use Only.
SKI-2852 (J2H-1702) is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.
SKI-2852 (J2H-1702) is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.
SKI-2852 demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity.
SKI-2852 significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.
