SKLB-197 | ATR inhibitor | Probechem Biochemicals

Chemical Structure : SKLB-197

CAS No.: 2713577-16-1

SKLB-197 (SKLB197)

Catalog No.: PC-72744Not For Human Use, Lab Use Only.

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.

Packing	Price	Stock
5 mg	$248	In stock
25 mg	$558	In stock
100 mg	$1480	In stock
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Biological Activity

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.
SKLB-197 displays very weak or no activity against other a panel of 402 protein kinases.
SKLB-197 exhibited potent antitumor activity against ATM-deficent tumors both in vitro and in vivo, with good pharmacokinetic properties.

Physicochemical Properties

M.Wt	424.508
Formula	C25H24N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

References

1. Huachao Bin, et al. Eur J Med Chem. 2022 Mar 15;232:114187.

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SKLB-197 (SKLB197)

Biological Activity

Physicochemical Properties

References

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