Chemical Structure : SKLB-197
CAS No.: 2713577-16-1
Catalog No.: PC-72744Not For Human Use, Lab Use Only.
SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.
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SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.
SKLB-197 displays very weak or no activity against other a panel of 402 protein kinases.
SKLB-197 exhibited potent antitumor activity against ATM-deficent tumors both in vitro and in vivo, with good pharmacokinetic properties.
M.Wt | 424.508 | |
Formula | C25H24N6O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- |
1. Huachao Bin, et al. Eur J Med Chem. 2022 Mar 15;232:114187.
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