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SKLB-197

Chemical Structure : SKLB-197

CAS No.: 2713577-16-1

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SKLB-197 (SKLB197)

Catalog No.: PC-72744Not For Human Use, Lab Use Only.

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.

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5 mg $248 In stock
25 mg $558 In stock
100 mg $1480 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.
SKLB-197 displays very weak or no activity against other a panel of 402 protein kinases.
SKLB-197 exhibited potent antitumor activity against ATM-deficent tumors both in vitro and in vivo, with good pharmacokinetic properties.

Physicochemical Properties

M.Wt 424.508
Formula C25H24N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Huachao Bin, et al. Eur J Med Chem. 2022 Mar 15;232:114187.

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