Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-EGFR-SKLB188
SKLB188

Chemical Structure : SKLB188

CAS No.: 1350545-09-3

Add to Favorites

SKLB188 (SKLB 188, SKLB-188)

Catalog No.: PC-61769Not For Human Use, Lab Use Only.

SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.
    SKLB188 inhibits a number of receptor tyrosine kinases, including Abl, Erb2, Erb4, Flt1, Flt3, Flt4, EphB, FGFR, c-Kit, Met, and PDGFR at 10 uM.
    SKLB188 potently inhibits the growth of HNSCC cells in vitro and in vivo by targeting EGFR signalling.
    SKLB188 inhibits FaDu xenograft growth in nude mice.

    Physicochemical Properties

    M.Wt 513.606
    Formula C27H31N9O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    9-cyclopentyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(3-nitrophenyl)-9H-purine-2,8-diamine

    References

    1. Barzegar M, et al. Br J Cancer. 2017 Sep 5. doi: 10.1038/bjc.2017.298.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: