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SKPin C1

Chemical Structure : SKPin C1

CAS No.: 432001-69-9

SKPin C1 (Skp2 Inhibitor C1, CKS1i, SKPin-C1)

Catalog No.: PC-62453Not For Human Use, Lab Use Only.

SKPin C1 (SKPin-C1, CKS1i) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, inhibits SCF-Skp2/Cks1 E3 ligase and blocks estrogen-induced growth stimulation and degradation of nuclear p27kip1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKPin C1 (SKPin-C1, CKS1i) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, inhibits SCF-Skp2/Cks1 E3 ligase and blocks estrogen-induced growth stimulation and degradation of nuclear p27kip1.
Skp2 inhibitor C1 (SKPin C1, CKS1i) induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases.

Physicochemical Properties

M.Wt 465.336
Formula C18H13BrN2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

References

1. Wu L, et al. Chem Biol. 2012 Dec 21;19(12):1515-24.
2. Grey W, et al. Sci Transl Med. 2022 Jun 22;14(650):eabn3248.

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