SLC-0111 (U-104) is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII.
SLC-0111 (U-104) showed selective CA IX/XII inhibitory profiles, displays >20-fold and >100-fold selectivity over hCA II and hCA I, respectively.
SLC-0111 (U-104) reduces tumor cell growth and increases apoptotic cell death in prostate cancer cells.
Physicochemical Properties
M.Wt
309.315
Formula
C13H12FN3O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(3-(4-fluorophenyl)ureido)benzenesulfonamide
References
1. Pacchiano F, et al. J Med Chem. 2011 Mar 24;54(6):1896-902.
2. Congiu C, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3.
3. Riemann A, et al. Oncol Res. 2017 Jun 19. doi: 10.3727/096504017X14965111926391.
