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SLC13A3 inhibitor ACA

Chemical Structure : SLC13A3 inhibitor ACA

CAS No.: 110683-10-8

SLC13A3 inhibitor ACA (BML264, (E/Z)-BML264)

Catalog No.: PC-23014Not For Human Use, Lab Use Only.

SLC13A3 inhibitor ACA ((E/Z)-BML264) is a small molecule inhibitor of SLC13A3, also is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.

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Biological Activity

SLC13A3 inhibitor ACA ((E/Z)-BML264) is a small molecule inhibitor of SLC13A3, also is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
SLC13A3 inhibitor ACA suppresses the growth of human HCC cells and prevents β-catenin-driven hepatocarcinogenesis in vivo.
SLC13A3 inhibitor ACA is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia.

Physicochemical Properties

M.Wt 337.42
Formula C21H23NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(p-amylcinnamoyl) anthranilic acid

References

1. Wennan Zhao, et al. Nat Commun. 2024 Aug 30;15(1):7522.

2. Bunse, L. et al. Nat. Med24, 1192–1203 (2018).

3. Kraft R, et al. Br J Pharmacol. 2006 Jun;148(3):264-73.

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