Chemical Structure : SLC6A19 inhibitor 20
CAS No.:
3102931-07-4
SLC6A19 inhibitor 20
Catalog No.: PC-28792Not For Human Use, Lab Use Only.
SLC6A19 inhibitor 20 is a potent, selective, and orally bioavailable allosteric SLC6A19 (B0AT1) inhibitor with IC50 of 21.5 nM and 207 nM for human and mouse SLC6A19 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SLC6A19 inhibitor 20 is a potent, selective, and orally bioavailable allosteric SLC6A19 (B0AT1) inhibitor with IC50 of 21.5 nM and 207 nM for human and mouse SLC6A19 respectively.
SLC6A19 inhibitor 20 inhibits SLC6A19 in non-human primates with IC50 of 38.0 nM.
shows no inhibitory activity for SLC6A20, human norepinephrine (NET, SLC6A2), dopamine (DAT, SLC6A3), and serotonin (SERT, SLC6A4) transporters.
SLC6A19 inhibitor 20 increases urinary amino acid excretion in a dose-dependent manner in human SLC6A19 knock-in mice and wild-type non-human primates.
Physicochemical Properties
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M.Wt
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347.80
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Formula
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C17H18ClN3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-({5-Chloro-6-[2-(1,2-oxazol-3-yl)ethoxy]-1H-indol-2-yl}methyl)propanamide
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References
1. Wang T, et al. J Med Chem. 2026 Nov 12;69(21):26102-26115.
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