Catalog No.: PC-38763Not For Human Use, Lab Use Only.
SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells.
SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells.
Administration of SLF1081851 to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2.
SLF1081851 shows the potential for development and use as a probe to investigate Spns2 biology and to determine the potential of Spns2 as a drug target.
