Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-Sphingosine kinase (SphK)-SLM6071469
SLM6071469

Chemical Structure : SLM6071469

CAS No.: 2676896-83-4

Add to Favorites

SLM6071469 (SM 6071469)

Catalog No.: PC-49707Not For Human Use, Lab Use Only.

SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.
    SLM6071469 shows improved potency and selectivity compared with SLM6031434.
    SLM6071469 inhibited SphK2 in vitro using recombinant protein and in yeast, SLM6071469 (10 mg/kg, i.p.) increased blood S1P levels in C57BL/6 mice.

    Physicochemical Properties

    M.Wt 499.42
    Formula C22H19F6N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(3-(3-(trifluoromethyl)-4-((4-(trifluoromethyl)benzyl)oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide

    References

    1. Sibley CD, et al. J Med Chem. 2020 Feb 13;63(3):1178-1198.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: