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Chemical Structure : SLM6071469
Catalog No.: PC-49707Not For Human Use, Lab Use Only.
SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.
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SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.
SLM6071469 shows improved potency and selectivity compared with SLM6031434.
SLM6071469 inhibited SphK2 in vitro using recombinant protein and in yeast, SLM6071469 (10 mg/kg, i.p.) increased blood S1P levels in C57BL/6 mice.
| M.Wt | 499.42 | |
| Formula | C22H19F6N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sibley CD, et al. J Med Chem. 2020 Feb 13;63(3):1178-1198.
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