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SLP9101555

Chemical Structure : SLP9101555

CAS No.: 1897380-29-8

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SLP9101555 (SLP 9101555)

Catalog No.: PC-49075Not For Human Use, Lab Use Only.

SLP9101555 is a potent, selective sphingosine kinase SphK2 with Ki of 90 nM (hSphK2), 200-fold selectivity over SphK1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SLP9101555 is a potent, selective sphingosine kinase SphK2 with Ki of 90 nM (hSphK2), 200-fold selectivity over SphK1.
    SLP9101555 is cell permeable and SLP9101555 (30-1000 nM) suppresses the conversion of FTY720 to FTY720-P in whole cells via inhibition of SphK2.
    SLP9101555 (5 mg/kg, i.p.) elicits profound increases in blood S1P concentration in in vivo testing in mice, a pharmacodynamic index of target engagement.

    Physicochemical Properties

    M.Wt 435.50
    Formula C22H28F3N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(3-(4-(2-Cyclohexylethyl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide

    References

    1. Srinath Pashikanti, et al. ACS Bio & Med Chem Au, 2022.

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