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SLV peptide

Chemical Structure : SLV peptide

CAS No.: 189109-89-5

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SLV peptide (Serine-Leucine-Valine;Ser-Leu-Val)

Catalog No.: PC-61257Not For Human Use, Lab Use Only.

A tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SLV peptide is a tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas.
    SLV peptide increases apoptosis sensitivity and decreases β-catenin in vitro, also decrease interaction of Fap1 with Apc, does not alter expression of Fap1 or Apc proteins.
    SLV peptide induces Fas-mediated apoptosis in a colon cancer cell line that expresses both Fas and FAP-1.

    Physicochemical Properties

    M.Wt 317.386
    Formula C14H27N3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Ser-Leu-Val

    References

    1. Huang W, et al. Leukemia. 2016 Jul;30(7):1502-9.

    2. Huang W, et al. J Biol Chem. 2013 May 3;288(18):12766-76.

    3. Yanagisawa J, et al. J Biol Chem. 1997 Mar 28;272(13):8539-45.

    4. Huang W, et al. Leuk Lymphoma. 2013 Mar;54(3):619-30.

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