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Chemical Structure : SLx-4090
CAS No.: 913541-47-6
Catalog No.: PC-60674Not For Human Use, Lab Use Only.
SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 25 mg | $468 | In stock | |
| 100 mg | Get quote |
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SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.
SLx-4090 inhibits apolipoprotein B (IC50=9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells.
SLx-4090 reduces postprandial lipids in rats with ED50 of 7 mg/kg, decreases the body weight gain and increases HDL-C in ApoE(−/−) mice.
| M.Wt | 546.546 | |
| Formula | C31H25F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(4'-Trifluoromethyl-6-methoxy-biphenyl-2-ylcarboxamido)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid phenyl ester |
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1. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.
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