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SLx-4090

Chemical Structure : SLx-4090

CAS No.: 913541-47-6

SLx-4090 (KD-026;SLx4090)

Catalog No.: PC-60674Not For Human Use, Lab Use Only.

SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.

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Biological Activity

SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.
SLx-4090 inhibits apolipoprotein B (IC50=9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells.
SLx-4090 reduces postprandial lipids in rats with ED50 of 7 mg/kg, decreases the body weight gain and increases HDL-C in ApoE(−/−) mice.

Physicochemical Properties

M.Wt 546.546
Formula C31H25F3N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(4'-Trifluoromethyl-6-methoxy-biphenyl-2-ylcarboxamido)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid phenyl ester

References

1. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.

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