SM-1295 |CAS:1562375-46-5 Probechem Biochemicals

Chemical Structure : SM-1295

SM-1295 (SM1295)

Catalog No.: PC-62351Not For Human Use, Lab Use Only.

SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP.

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Biological Activity

SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP.
SM-1295 potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations.
SM-1295 efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3.
SM-1295 induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines.

Physicochemical Properties

M.Wt	598.542
Formula	C29H36BrN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrrolo[1,2-a][1,5]diazocine-8-carboxamide, N-[(4-bromophenyl)methyl]decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-6-oxo-3-(2-phenylacetyl)-, (5S,8S,10aR)-

References

1. Sun H, et al. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.

SM-1295 (SM1295)

Biological Activity

Physicochemical Properties

References

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