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SM-368229

Chemical Structure : SM-368229

CAS No.: 899437-40-2

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SM-368229 (SM368229)

Catalog No.: PC-25374Not For Human Use, Lab Use Only.

SM-368229 is a potent, selective mineralocorticoid receptor (MR) antagonist with IC50 of 21 and 120 nM in binding assay and reporter-gene assay, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SM-368229 is a potent, selective mineralocorticoid receptor (MR) antagonist with IC50 of 21 and 120 nM in binding assay and reporter-gene assay, respectively.
    SM-368229 is 18-fold selective over other steroid receptors, such as androgen, progesterone, and glucocorticoid receptors.
    SM-368229 dose-dependently increased urinary Na+/K+ ratio with an ED50 value of 5.6 mg/kg in adrenalectomized rats treated with deoxycorticosterone acetate.

    Physicochemical Properties

    M.Wt 354.46
    Formula C14H14N2O3S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4,4-dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)thiophene-2-sulfonamide

    References

    1. Nariai T, et al. J Pharmacol Sci. 2011;115(3):346-53.

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